The Modulation of Cholesterol Metabolism Is Involved in the Antiviral Effect of Nitazoxanide

• Main Authors: Claudio Fenizia (Author), Salomè Valentina Ibba (Author), Claudia Vanetti (Author), Sergio Strizzi (Author), Jean-François Rossignol (Author), Mara Biasin (Author), Daria Trabattoni (Author), Mario Clerici (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously investigated the role of Nitazoxanide (NTZ), a thiazolide endowed with antiviral and antiparasitic activity, in HIV-1 infection. NTZ treatment in primary isolated PBMCs was able to reduce HIV-1 infection in vitro by inducing the expression of a number of type-I interferon-stimulated ge...