Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice

• Main Authors: Vanessa Rodrigues Vilela (Author), Nolwenn Samson (Author), Renato Nachbar (Author), Lia Rossi Perazza (Author), Gabriel Lachance (Author), Volatiana Rokatoarivelo (Author), Carolina Centano-Baez (Author), Patricia Zancan (Author), Mauro Sola-Penna (Author), Kerstin Bellmann (Author), Vincenzo Di Marzo (Author), Mathieu Laplante (Author), André Marette (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Inducible nitric oxide (NO) synthase (NOS2) is a well-documented inflammatory mediator of insulin resistance in obesity. NOS2 expression is induced in both adipocytes and macrophages within adipose tissue during high-fat (HF)-induced obesity. Methods: Eight-week-old male mice with adipocy...