Adipocyte-specific Nos2 deletion improves insulin resistance and dyslipidemia through brown fat activation in diet-induced obese mice

• Κύριοι συγγραφείς: Vanessa Rodrigues Vilela (Συγγραφέας), Nolwenn Samson (Συγγραφέας), Renato Nachbar (Συγγραφέας), Lia Rossi Perazza (Συγγραφέας), Gabriel Lachance (Συγγραφέας), Volatiana Rokatoarivelo (Συγγραφέας), Carolina Centano-Baez (Συγγραφέας), Patricia Zancan (Συγγραφέας), Mauro Sola-Penna (Συγγραφέας), Kerstin Bellmann (Συγγραφέας), Vincenzo Di Marzo (Συγγραφέας), Mathieu Laplante (Συγγραφέας), André Marette (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2022-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Objective: Inducible nitric oxide (NO) synthase (NOS2) is a well-documented inflammatory mediator of insulin resistance in obesity. NOS2 expression is induced in both adipocytes and macrophages within adipose tissue during high-fat (HF)-induced obesity. Methods: Eight-week-old male mice with adipocy...