Leishmania infantum Asparagine Synthetase A Is Dispensable for Parasites Survival and Infectivity.

• Egile Nagusiak: Joana Faria (Egilea), Inês Loureiro (Egilea), Nuno Santarém (Egilea), Sandra Macedo-Ribeiro (Egilea), Joana Tavares (Egilea), Anabela Cordeiro- (Egilea)
• Formatua: Liburua
• Argitaratua: Public Library of Science (PLoS), 2016-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A growing interest in asparagine (Asn) metabolism has currently been observed in cancer and infection fields. Asparagine synthetase (AS) is responsible for the conversion of aspartate into Asn in an ATP-dependent manner, using ammonia or glutamine as a nitrogen source. There are two structurally dis...