Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound

• প্রধান লেখক: Justyna Knapik-Kowalczuk (লেখক), Krzysztof Chmiel (লেখক), Justyna Pacułt (লেখক), Klaudia Bialek (লেখক), Lidia Tajber (লেখক), Marian Paluch (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2020-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

The main purpose of this paper was to evaluate the impact of both high- and low-T_g polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly affected by the polymeric excipients used (Kollidon...