Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound

• Asıl Yazarlar: Justyna Knapik-Kowalczuk (Yazar), Krzysztof Chmiel (Yazar), Justyna Pacułt (Yazar), Klaudia Bialek (Yazar), Lidia Tajber (Yazar), Marian Paluch (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-05-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The main purpose of this paper was to evaluate the impact of both high- and low-T_g polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly affected by the polymeric excipients used (Kollidon...