Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound

• Main Authors: Justyna Knapik-Kowalczuk (Author), Krzysztof Chmiel (Author), Justyna Pacułt (Author), Klaudia Bialek (Author), Lidia Tajber (Author), Marian Paluch (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2020-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The main purpose of this paper was to evaluate the impact of both high- and low-T_g polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly affected by the polymeric excipients used (Kollidon...