Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases

• Main Authors: Ivan Bradić (Author), Katharina B. Kuentzel (Author), Sophie Honeder (Author), Gernot F. Grabner (Author), Nemanja Vujić (Author), Robert Zimmermann (Author), Ruth Birner-Gruenberger (Author), Dagmar Kratky (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Lysosomal acid lipase (LAL) is the key enzyme, which degrades neutral lipids at an acidic pH in lysosomes. The role of LAL in various cellular processes has mostly been studied in LAL-knockout mice, which share phenotypical characteristics with humans suffering from LAL deficiency. In vi...