Concurrent somatic KRAS mutation and germline 10q22.3-q23.2 deletion in a patient with juvenile myelomonocytic leukemia, developmental delay, and multiple malformations: a case report

• Үндсэн зохиолчид: Ruen Yao (Зохиогч), Tingting Yu (Зохиогч), Yufei Xu (Зохиогч), Guoqiang Li (Зохиогч), Lei Yin (Зохиогч), Yunfang Zhou (Зохиогч), Jian Wang (Зохиогч), Zhilong Yan (Зохиогч)
• Формат: Ном
• Хэвлэсэн: BMC, 2018-07-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Background The proto-oncogene KRAS performs an essential function in normal tissue signaling, and the mutation of KRAS gene is a key step in the development of many cancers. Somatic KRAS mutations are often detected in patients with solid and non-solid tumors, whereas germline KRAS mutation...