Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation

• Main Authors: Rosa Catera (Author), Yun Liu (Author), Chao Gao (Author), Xiao-Jie Yan (Author), Amanda Magli (Author), Steven L. Allen (Author), Jonathan E. Kolitz (Author), Kanti R. Rai (Author), Charles C. Chu (Author), Ten Feizi (Author), Kostas Stamatopoulos (Author), Nicholas Chiorazzi (Author)
• Format: Book
• Published: BMC, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this are CLL subset 4 BCR IGs using IGHV4-34/IGHD5-18/...