Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators

• Main Authors: Onofrio Laselva (Author), Giovanni Marzaro (Author), Christian Vaccarin (Author), Ilaria Lampronti (Author), Anna Tamanini (Author), Giuseppe Lippi (Author), Roberto Gambari (Author), Giulio Cabrini (Author), Christine E. Bear (Author), Adriana Chilin (Author), Maria C. Dechecchi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The psoralen-related compound, 4,6,4'-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like l...