Formyl-Peptide Receptor 2 Signaling Modulates SLC7A11/xCT Expression and Activity in Tumor Cells

• Главные авторы: Tiziana Pecchillo Cimmino (Автор), Carolina Punziano (Автор), Iolanda Panico (Автор), Zeudi Petrone (Автор), Myrhiam Cassese (Автор), Raffaella Faraonio (Автор), Vincenza Barresi (Автор), Gabriella Esposito (Автор), Rosario Ammendola (Автор), Fabio Cattaneo (Автор)
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• Опубликовано: MDPI AG, 2024-04-01T00:00:00Z.
• Предметы: article
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Cancer cells exhibit high levels of oxidative stress and consequently require a high amount of cysteine for glutathione synthesis. Solute Carrier Family 7 Member 11 (SLC7A11), or xCT, mediates the cellular uptake of cystine in exchange for intracellular glutamate; imported extracellular cystine is r...