Formyl-Peptide Receptor 2 Signaling Modulates SLC7A11/xCT Expression and Activity in Tumor Cells

• Main Authors: Tiziana Pecchillo Cimmino (Author), Carolina Punziano (Author), Iolanda Panico (Author), Zeudi Petrone (Author), Myrhiam Cassese (Author), Raffaella Faraonio (Author), Vincenza Barresi (Author), Gabriella Esposito (Author), Rosario Ammendola (Author), Fabio Cattaneo (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer cells exhibit high levels of oxidative stress and consequently require a high amount of cysteine for glutathione synthesis. Solute Carrier Family 7 Member 11 (SLC7A11), or xCT, mediates the cellular uptake of cystine in exchange for intracellular glutamate; imported extracellular cystine is r...