Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

• Main Authors: Ashley P. Dudey (Author), Jake M. Rigby (Author), Gregory R. Hughes (Author), G. Richard Stephenson (Author), Thomas E. Storr (Author), Andrew Chantry (Author), Andrew M. Hemmings (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...