Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

• मुख्य लेखकों: Ashley P. Dudey (लेखक), Jake M. Rigby (लेखक), Gregory R. Hughes (लेखक), G. Richard Stephenson (लेखक), Thomas E. Storr (लेखक), Andrew Chantry (लेखक), Andrew M. Hemmings (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...