Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...

Full description

Saved in:
Bibliographic Details
Main Authors: Ashley P. Dudey (Author), Jake M. Rigby (Author), Gregory R. Hughes (Author), G. Richard Stephenson (Author), Thomas E. Storr (Author), Andrew Chantry (Author), Andrew M. Hemmings (Author)
Format: Book
Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
Subjects:
article
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available

Similar Items