Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases

• 主要な著者: Ashley P. Dudey (著者), Jake M. Rigby (著者), Gregory R. Hughes (著者), G. Richard Stephenson (著者), Thomas E. Storr (著者), Andrew Chantry (著者), Andrew M. Hemmings (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The HECT E3 ubiquitin ligases 1 (WWP1) and 2 (WWP2) are responsible for the ubiquitin-mediated degradation of key tumour suppressor proteins and are dysregulated in various cancers and diseases. Here we expand their limited inhibitor space by identification of NSC-217913 displaying a WWP1 IC50 of 15...