Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin‐induced nephrotoxicity

• Main Authors: Sumith K. Mathew (Author), Aaron Chapla (Author), Padmanaban Venkatesan (Author), Vishnu Eriyat (Author), Blessed Winston Aruldhas (Author), Ratna Prabha (Author), Michael N. Neely (Author), Shoma V. Rao (Author), Subramani Kandasamy (Author), Binu Susan Mathew (Author)
• Format: Book
• Published: Wiley, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Colistin is known to cause nephrotoxicity due to its extensive reabsorption and accumulation in renal tubules. In vitro studies have identified the functional role of colistin transporters such as OCTN2, PEPT2, megalin, and P‐glycoprotein. However, the role of these transporter gene variant...