Effect of Heme Oxygenase-1 on Melanoma Development in Mice-Role of Tumor-Infiltrating Immune Cells

• Main Authors: Halina Was (Author), Tomasz Cichon (Author), Ryszard Smolarczyk (Author), Bozena Lackowska (Author), Agnieszka Mazur-Bialy (Author), Magdalena Mazur (Author), Agata Szade (Author), Pawel Dominik (Author), Milena Mazan (Author), Jerzy Kotlinowski (Author), Anna Zebzda (Author), Anna Kusienicka (Author), Claudine Kieda (Author), Jozef Dulak (Author), Alicja Jozkowicz (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Heme oxygenase-1 (HO-1) is a cytoprotective, proangiogenic and anti-inflammatory enzyme that is often upregulated in tumors. Overexpression of HO-1 in melanoma cells leads to enhanced tumor growth, augmented angiogenesis and resistance to anticancer treatment. The effect of HO-1 in host c...