Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High Glucose

• Main Authors: Ling Zhang (Author), Jianguo Wang (Author), Yu Tina Zhao (Author), Patrycja Dubielecka (Author), Gangjian Qin (Author), Shougang Zhuang (Author), Eugene Y Chin (Author), Paul Y Liu (Author), Ting C Zhao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: p38 regulated/activated protein kinase (PRAK) plays a crucial role in modulating cell death and survival. However, the role of PRAK in the regulation of metabolic stress remains unclear. We examined the effects of PRAK on cell survival and mitochondrial function in C2C12 myoblasts in res...