Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

• Main Authors: Mario Rotondi (Author), Francesca Coperchini (Author), Oriana Awwad (Author), Patrizia Pignatti (Author), Christian A. Di Buduo (Author), Vittorio Abbonante (Author), Flavia Magri (Author), Alessandra Balduini (Author), Luca Chiovato (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer...