Synthesis and Characterization of a Biomimetic Formulation of Clofazimine Hydrochloride Microcrystals for Parenteral Administration

• Main Authors: Mikhail D. Murashov (Author), Jennifer Diaz-Espinosa (Author), Vernon LaLone (Author), Joel W. Y. Tan (Author), Raluca Laza (Author), Xueding Wang (Author), Kathleen A. Stringer (Author), Gus R. Rosania (Author)
• Format: Book
• Published: MDPI AG, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as a first line treatment for leprosy and second line treatment for multidrug resistant tuberculosis. Oral administration of CFZ leads to a red skin pigmentation side effect. Since CFZ is a wea...