Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

• Main Authors: Luka Brcic (Author), Christian Kuchler (Author), Sylvia Eidenhammer (Author), Daniela Pabst (Author), Franz Quehenberger (Author), Adi F. Gazdar (Author), Helmut Popper (Author)
• Format: Book
• Published: BMC, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate directed against DLL3, showed promising results. A pr...