Comparison of four DLL3 antibodies performance in high grade neuroendocrine lung tumor samples and cell cultures

• Principais autores: Luka Brcic (Autor), Christian Kuchler (Autor), Sylvia Eidenhammer (Autor), Daniela Pabst (Autor), Franz Quehenberger (Autor), Adi F. Gazdar (Autor), Helmut Popper (Autor)
• Formato: Livro
• Publicado em: BMC, 2019-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Small cell lung cancer (SCLC) is usually diagnosed in the advanced stage. It has a very poor prognosis, with no advancements in therapy in the last few decades. A recent phase 1 clinical study, using an antibody-drug conjugate directed against DLL3, showed promising results. A pr...