Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

• Egile Nagusiak: Yulia Grishchuk (Egilea), Karina A. Peña (Egilea), Jessica Coblentz (Egilea), Victoria E. King (Egilea), Daniel M. Humphrey (Egilea), Shirley L. Wang (Egilea), Kirill I. Kiselyov (Egilea), Susan A. Slaugenhaupt (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2015-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the MCOLN1 gene, which encodes the lysosomal transient receptor potential ion channel mucolipin-1 (TRPML1). MLIV causes impaired motor and cognitive development, progressive loss of vision and gastric achlorhydria. Ho...