Impaired myelination and reduced brain ferric iron in the mouse model of mucolipidosis IV

• Main Authors: Yulia Grishchuk (Author), Karina A. Peña (Author), Jessica Coblentz (Author), Victoria E. King (Author), Daniel M. Humphrey (Author), Shirley L. Wang (Author), Kirill I. Kiselyov (Author), Susan A. Slaugenhaupt (Author)
• Format: Book
• Published: The Company of Biologists, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mucolipidosis type IV (MLIV) is a lysosomal storage disease caused by mutations in the MCOLN1 gene, which encodes the lysosomal transient receptor potential ion channel mucolipin-1 (TRPML1). MLIV causes impaired motor and cognitive development, progressive loss of vision and gastric achlorhydria. Ho...