Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

• Main Authors: Shuyi Wang (Author), Jun Tao (Author), Huaguo Chen (Author), Machender R. Kandadi (Author), Mingming Sun (Author), Haixia Xu (Author), Gary D. Lopaschuk (Author), Yan Lu (Author), Junmeng Zheng (Author), Hu Peng (Author), Jun Ren (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis. Akt2-Ampkα2 double knockout (DKO) mice were placed on high fat diet for 5 months. Glucose metaboli...