Development of a population pharmacokinetic model of pyrazinamide to guide personalized therapy: impacts of geriatric and diabetes mellitus on clearance

• Main Authors: Ryunha Kim (Author), Rannissa Puspita Jayanti (Author), Hongyeul Lee (Author), Hyun-Kuk Kim (Author), Jiyeon Kang (Author), I-Nae Park (Author), Jehun Kim (Author), Jee Youn Oh (Author), Hyung Woo Kim (Author), Heayon Lee (Author), Jong-Lyul Ghim (Author), Sangzin Ahn (Author), Nguyen Phuoc Long (Author), Yong-Soon Cho (Author), Jae-Gook Shin (Author), On behalf of the cPMTb (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: This study was performed to develop a population pharmacokinetic model of pyrazinamide for Korean tuberculosis (TB) patients and to explore and identify the influence of demographic and clinical factors, especially geriatric diabetes mellitus (DM), on the pharmacokinetics (PK) of pyrazin...