Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway

Methotrexate (MTX) is a well-known anticancer drug that causes nephrotoxicity as a side effect. To investigate the mechanisms by which paeonol, a natural phenolic compound, can protect against MTX-induced nephrotoxicity, paeonol (100 mg/kg/day orally) was given to rats for 10 days, with or without M...

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Main Authors: Mohamed A. Morsy (Author), Azza A. K. El-Sheikh (Author), Sara Mohamed Naguib Abdel-Hafez (Author), Mahmoud Kandeel (Author), Seham A. Abdel-Gaber (Author)
Format: Book
Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
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3rd Floor Main Library

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