Total tanshinones ameliorates cGAS-STING-mediated inflammatory and autoimmune diseases by affecting STING-IRF3 binding

• Main Authors: Chengwei Li (Author), Jincai Wen (Author), Xiaoyan Zhan (Author), Wei Shi (Author), Xiu Ye (Author), Qing Yao (Author), Simin Chen (Author), Congyang Zheng (Author), Xianlin Wang (Author), Xinru Wen (Author), Xiaohe Xiao (Author), Yinghao Wang (Author), Zhaofang Bai (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background An important signaling pathway connecting illness and natural immunity is the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, but aberrant activation of this pathway is associated with the development of autoimmune and inflammatory diseases. Hence,...