Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia

• Những tác giả chính: Dennis Kätzel (Tác giả), Amy R. Wolff (Tác giả), Alexei M. Bygrave (Tác giả), David M. Bannerman (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives maladaptive learning chronically during disease dev...