Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia

• Egile Nagusiak: Dennis Kätzel (Egilea), Amy R. Wolff (Egilea), Alexei M. Bygrave (Egilea), David M. Bannerman (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives maladaptive learning chronically during disease dev...