Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis

• Main Authors: Jane Carr-Wilkinson (Author), Nilendran Prathalingam (Author), Deepali Pal (Author), Mohammad Moad (Author), Natalie Lee (Author), Aishwarya Sundaresh (Author), Helen Forgham (Author), Peter James (Author), Mary Herbert (Author), Majlinda Lako (Author), Deborah A. Tweddle (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2018-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Background and Aims. Previous studies modelling human neural crest differentiation from stem cells have resulted in a low yield of sympathetic neurons. Our aim was to optimise a method for the differentiation of human embryonic stem cells (hESCs) to sympathetic neuron-like cells (SN) to model normal...