The p97‐Nploc4 ATPase complex plays a role in muscle atrophy during cancer and amyotrophic lateral sclerosis

• Main Authors: Andrea David Re Cecconi (Author), Mara Barone (Author), Simona Gaspari (Author), Massimo Tortarolo (Author), Caterina Bendotti (Author), Luca Porcu (Author), Giulia Terribile (Author), Rosanna Piccirillo (Author)
• Format: Book
• Published: Wiley, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The p97 complex participates in the degradation of muscle proteins during atrophy upon fasting or denervation interacting with different protein adaptors. We investigated whether and how it might also be involved in muscle wasting in cancer, where loss of appetite occurs, or amyo...