Doxorubicin Induces Apoptosis by Activation of Caspase-3 in Cultured Cardiomyocytes In Vitro and Rat Cardiac Ventricles In Vivo

• Hoofdauteurs: Ueno Michihiko (Auteur), Kakinuma Yoshihiko (Auteur), Yuhki Koh-ichi (Auteur), Murakoshi Nobuyuki (Auteur), Iemitsu Motoyuki (Auteur), Miyauchi Takashi (Auteur), Yamaguchi Iwao (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2006-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract.: Doxorubicin (DOX) is widely used to treat patients suffering from cancer, but the usage for patients is limited because of the dose-dependent cardiotoxicity. We hypothesized that DOX induces apoptosis through caspase activation in cardiomyocytes, and we examined this hypothesis using both...