Doxorubicin Induces Apoptosis by Activation of Caspase-3 in Cultured Cardiomyocytes In Vitro and Rat Cardiac Ventricles In Vivo

• Autores principales: Ueno Michihiko (Autor), Kakinuma Yoshihiko (Autor), Yuhki Koh-ichi (Autor), Murakoshi Nobuyuki (Autor), Iemitsu Motoyuki (Autor), Miyauchi Takashi (Autor), Yamaguchi Iwao (Autor)
• Formato: Libro
• Publicado: Elsevier, 2006-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract.: Doxorubicin (DOX) is widely used to treat patients suffering from cancer, but the usage for patients is limited because of the dose-dependent cardiotoxicity. We hypothesized that DOX induces apoptosis through caspase activation in cardiomyocytes, and we examined this hypothesis using both...