Doxorubicin Induces Apoptosis by Activation of Caspase-3 in Cultured Cardiomyocytes In Vitro and Rat Cardiac Ventricles In Vivo

• Main Authors: Ueno Michihiko (Author), Kakinuma Yoshihiko (Author), Yuhki Koh-ichi (Author), Murakoshi Nobuyuki (Author), Iemitsu Motoyuki (Author), Miyauchi Takashi (Author), Yamaguchi Iwao (Author)
• Format: Bog
• Udgivet: Elsevier, 2006-01-01T00:00:00Z.
• Fag: article
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Abstract.: Doxorubicin (DOX) is widely used to treat patients suffering from cancer, but the usage for patients is limited because of the dose-dependent cardiotoxicity. We hypothesized that DOX induces apoptosis through caspase activation in cardiomyocytes, and we examined this hypothesis using both...