Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

• Main Authors: José Carlos Solana (Author), Laura Ramírez (Author), Laura Corvo (Author), Camila Indiani de Oliveira (Author), Manoel Barral-Netto (Author), José María Requena (Author), Salvador Iborra (Author), Manuel Soto (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The immunization with genetically attenuated Leishmania cell lines has been associated to the induction of memory and effector T cell responses against Leishmania able to control subsequent challenges. A Leishmania infantum null mutant for the HSP70-II genes has been described, possessing a non-viru...