Vaccination with a Leishmania infantum HSP70-II null mutant confers long-term protective immunity against Leishmania major infection in two mice models.

• Autores principales: José Carlos Solana (Autor), Laura Ramírez (Autor), Laura Corvo (Autor), Camila Indiani de Oliveira (Autor), Manoel Barral-Netto (Autor), José María Requena (Autor), Salvador Iborra (Autor), Manuel Soto (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The immunization with genetically attenuated Leishmania cell lines has been associated to the induction of memory and effector T cell responses against Leishmania able to control subsequent challenges. A Leishmania infantum null mutant for the HSP70-II genes has been described, possessing a non-viru...