ON THE PRO-METASTATIC STRESS RESPONSE TO CANCER THERAPIES: EVIDENCE FOR A POSITIVE CO-OPERATION BETWEEN TIMP-1, HIF-1α, AND miR-210

• Main Authors: Haissi eCui (Author), Sebastien eGrosso (Author), Florian eSchelter (Author), Bernard eMari (Author), Achim eKrüger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In contrast to expectations in the past that tumor starvation or unselective inhibition of proteolytic activity would cure cancer, there is accumulating evidence that microenvironmental stress, such as hypoxia or broad spectrum inhibition of metalloproteinases can promote metastasis. In fact, malign...