Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers

• Main Authors: Ioana Todor (Author), Adina Popa (Author), Maria Neag (Author), Dana Muntean (Author), Corina Bocsan (Author), Anca Buzoianu (Author), Laurian Vlase (Author), Ana-Maria Gheldiu (Author), Corina Briciu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: To evaluate the impact of bupropion on the pharmacokinetic profile of atomoxetine and its main active metabolite (glucuronidated form), 4-hydroxyatomoxetine-O-glucuronide, in healthy volunteers. Methods: An open-label, non-randomized, two-period, sequential clinical trial was conducted as f...