Peroxisome Proliferator-Activated Receptor α Attenuates Hypertensive Vascular Remodeling by Protecting Vascular Smooth Muscle Cells from Angiotensin II-Induced ROS Production

• Main Authors: Ye Liu (Author), Yan Duan (Author), Nan Zhao (Author), Xinxin Zhu (Author), Xiaoting Yu (Author), Shiyu Jiao (Author), Yanting Song (Author), Li Shi (Author), Yutao Ma (Author), Xia Wang (Author), Baoqi Yu (Author), Aijuan Qu (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vascular remodeling is the fundamental basis for hypertensive disease, in which vascular smooth muscle cell (VSMC) dysfunction plays an essential role. Previous studies suggest that the activation of peroxisome proliferator-activated receptor α (PPARα) by fibrate drugs has cardiovascular benefits in...