Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition

• Main Authors: Shaohua Xu (Author), Ruolan Fan (Author), Lu Wang (Author), Weishen He (Author), Haixia Ge (Author), Hailan Chen (Author), Wen Xu (Author), Jian Zhang (Author), Wei Xu (Author), Yaqian Feng (Author), Zhimin Fan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Using STAT3 inhibitors as a potential strategy in cancer therapy have attracted much attention. Recently, celastrol has been reported that it could directly bind to and suppress the activity of STAT3 in the cardiac dysfunction model. To explore more effective STAT3 inhibiting anti-tumour drug candid...