Synthesis and biological evaluation of celastrol derivatives as potent antitumor agents with STAT3 inhibition

• मुख्य लेखकों: Shaohua Xu (लेखक), Ruolan Fan (लेखक), Lu Wang (लेखक), Weishen He (लेखक), Haixia Ge (लेखक), Hailan Chen (लेखक), Wen Xu (लेखक), Jian Zhang (लेखक), Wei Xu (लेखक), Yaqian Feng (लेखक), Zhimin Fan (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2022-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Using STAT3 inhibitors as a potential strategy in cancer therapy have attracted much attention. Recently, celastrol has been reported that it could directly bind to and suppress the activity of STAT3 in the cardiac dysfunction model. To explore more effective STAT3 inhibiting anti-tumour drug candid...