ACOX1 deficiency-induced lipid metabolic disorder facilitates chronic interstitial fibrosis development in renal allografts

• Main Authors: Yang-He Zhang (Author), Bin Liu (Author), Qingfei Meng (Author), Dan Zhang (Author), Hongxia Yang (Author), Guangtao Li (Author), Yuxiong Wang (Author), Mingdi Liu (Author), Nian Liu (Author), Jinyu Yu (Author), Si Liu (Author), Honglan Zhou (Author), Zhi-Xiang Xu (Author), Yishu Wang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic interstitial fibrosis presents a significant challenge to the long-term survival of transplanted kidneys. Our research has shown that reduced expression of acyl-coenzyme A oxidase 1 (ACOX1), which is the rate-limiting enzyme in the peroxisomal fatty acid β-oxidation pathway, contributes to t...