Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach

• Main Authors: Giuseppina De Simone (Author), Anna Di Fiore (Author), Emanuela Truppo (Author), Emma Langella (Author), Daniela Vullo (Author), Claudiu T. Supuran (Author), Simona Maria Monti (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Carbonic anhydrases (CAs) are ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide to bicarbonate and proton. In humans there are 15 isoforms among which only 12 are catalytically active. Since active human (h) CAs show different efficiency, the understanding of the mo...