High sulfation and a high molecular weight are important for anti-hepcidin activity of heparin

• Main Authors: Michela eAsperti (Author), Annamaria eNaggi (Author), Emiliano eEsposito (Author), Paola eRuzzenenti (Author), Margherita eDi Somma (Author), Magdalena eGryzik (Author), Paolo eArosio (Author), Maura ePoli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heparins are efficient inhibitors of hepcidin expression even in vivo, where they induce an increase of systemic iron availability. Heparins seem to act by interfering with BMP6 signaling pathways that control the expression of liver hepcidin, causing the suppression of SMAD1/5/8 phosphorylation. Th...