SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes

• Main Authors: Katterine Salazar (Author), Francisca Espinoza (Author), Gustavo Cerda-Gallardo (Author), Luciano Ferrada (Author), Rocío Magdalena (Author), Eder Ramírez (Author), Viviana Ulloa (Author), Natalia Saldivia (Author), Ninoschka Troncoso (Author), María José Oviedo (Author), María José Barahona (Author), Fernando Martínez (Author), Francisco Nualart (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During brain development, sodium-vitamin C transporter (SVCT2) has been detected primarily in radial glial cells in situ, with low-to-absent expression in cerebral cortex neuroblasts. However, strong SVCT2 expression is observed during the first postnatal days, resulting in increased intracellular c...