Degradation rates and products of fluticasone propionate in alkaline solutions

• Main Authors: Tadakazu Tokumura (Author), Naoko Yoshida (Author), Kanami Mori-Yasumoto (Author), Osamu Shirota (Author), Takuro Kurita (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The apparent degradation rate constant of fluticasone propionate (FLT) in 0.1 M NaOH:methanol=1:1 at 37 °C was previously reported to be 0.169±0.003 h−1, and four degradation products (products 1-4) were observed in the solution. The aims of the present study were to assess the degradation rates of...