HIF-1 transcription activity: HIF1A driven response in normoxia and in hypoxia

• Main Authors: Flora Cimmino (Author), Marianna Avitabile (Author), Vito Alessandro Lasorsa (Author), Annalaura Montella (Author), Lucia Pezone (Author), Sueva Cantalupo (Author), Feliciano Visconte (Author), Maria Valeria Corrias (Author), Achille Iolascon (Author), Mario Capasso (Author)
• Format: Book
• Published: BMC, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background HIF1A (Hypoxia-Inducible-Factor 1A) expression in solid tumors is relevant to establish resistance to therapeutic approaches. The use of compounds direct against hypoxia signaling and HIF1A does not show clinical efficiency because of changeable oxygen concentrations in solid tum...