Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles

• Hoofdauteurs: Livio Racané (Auteur), Valentina Rep (Auteur), Sandra Kraljević Pavelić (Auteur), Petra Grbčić (Auteur), Iva Zonjić (Auteur), Marijana Radić Stojković (Auteur), Martin C. Taylor (Auteur), John M. Kelly (Auteur), Silvana Raić-Malić (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines and the protozoan parasite Trypanosoma brucei. The influence of the type...