Synthesis, antiproliferative and antitrypanosomal activities, and DNA binding of novel 6-amidino-2-arylbenzothiazoles

• Main Authors: Livio Racané (Author), Valentina Rep (Author), Sandra Kraljević Pavelić (Author), Petra Grbčić (Author), Iva Zonjić (Author), Marijana Radić Stojković (Author), Martin C. Taylor (Author), John M. Kelly (Author), Silvana Raić-Malić (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 6-amidinobenzothiazoles, linked via phenoxymethylene or directly to the 1,2,3-triazole ring with a p-substituted phenyl or benzyl moiety, were synthesised and evaluated in vitro against four human tumour cell lines and the protozoan parasite Trypanosoma brucei. The influence of the type...