Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model

• Main Authors: Martin Crivello (Author), Marion C. Hogg (Author), Elisabeth Jirström (Author), Luise Halang (Author), Ina Woods (Author), Megan Rayner (Author), Karen S. Coughlan (Author), Sebastian A. Lewandowski (Author), Jochen H. M. Prehn (Author)
• Formato: Livro
• Publicado em: The Company of Biologists, 2019-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) presents a poorly understood pathogenesis. Evidence from patients and mutant SOD1 mouse models suggests vascular damage may precede or aggravate motor dysfunction in ALS. We have previously shown angiogenin (ANG) treatment enhances motor neuron survival, delays mo...