In Vitro and In Vivo Studies for the Investigation of γ-Globin Gene Induction by Adhatoda vasica: A Pre-Clinical Study of HbF Inducers for β-Thalassemia

• Main Authors: Fizza Iftikhar (Author), Saeedur Rahman (Author), Muhammad Behroz Naeem Khan (Author), Kanwal Khan (Author), Muhammad Noman Khan (Author), Reaz Uddin (Author), Syed Ghulam Musharraf (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Fag: article
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Fetal hemoglobin (HbF) is a potent genetic modifier, and the γ-globin gene induction has proven to be a sustainable therapeutic approach for the management of β-thalassemia. In this study, we have evaluated the HbF induction ability of A. vasica in vitro and in vivo, and the identification of potent...