Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia

• Main Authors: Xuan Gao (Author), Xiao-Wen Qian (Author), Xiao-Hua Zhu (Author), Yi Yu (Author), Hui Miao (Author), Jian-Hua Meng (Author), Jun-Ye Jiang (Author), Hong-Sheng Wang (Author), Xiao-Wen Zhai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-dose methotrexate (HD-MTX) is widely used in pediatric acute lymphoblastic leukemia (ALL) treatment regimens. In this study, we aimed to develop a population pharmacokinetic (PK) model of HD-MTX in Chinese pediatric patients with ALL for designing personalized dosage regimens. In total, 4,517 M...