Semimechanistic models to relate noxious stimulation, movement, and pupillary dilation responses in the presence of opioids

• Main Authors: Nicolás Marco‐Ariño (Author), Sergio Vide (Author), Mercè Agustí (Author), Andrew Chen (Author), Sebastián Jaramillo (Author), Itziar Irurzun‐Arana (Author), Adrià Pacheco (Author), Carmen Gonzalez (Author), Erik W. Jensen (Author), Patricia Capsi‐Morales (Author), José F. Valencia (Author), Iñaki F. Troconiz (Author), Pedro L. Gambus (Author), Merlin D. Larson (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Intraoperative targeting of the analgesic effect still lacks an optimal solution. Opioids are currently the main drug used to achieve antinociception, and although underdosing can lead to an increased stress response, overdose can also lead to undesirable adverse effects. To better understa...