A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

• मुख्य लेखकों: Sharon M. Rymut (लेखक), Lindsay M. Henderson (लेखक), Victor Poon (लेखक), Tracy L. Staton (लेखक), Fang Cai (लेखक), Siddharth Sukumaran (लेखक), Horace Rhee (लेखक), Ryan Owen (लेखक), Saroja Ramanujan (लेखक), Kenta Yoshida (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active tetramer into inactive monomers. This s...