A mechanistic PK/PD model to enable dose selection of the potent anti‐tryptase antibody (MTPS9579A) in patients with moderate‐to‐severe asthma

• Egile Nagusiak: Sharon M. Rymut (Egilea), Lindsay M. Henderson (Egilea), Victor Poon (Egilea), Tracy L. Staton (Egilea), Fang Cai (Egilea), Siddharth Sukumaran (Egilea), Horace Rhee (Egilea), Ryan Owen (Egilea), Saroja Ramanujan (Egilea), Kenta Yoshida (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2023-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Tryptase, a protease implicated in asthma pathology, is secreted from mast cells upon activation during an inflammatory allergic response. MTPS9579A is a novel monoclonal antibody that inhibits tryptase activity by irreversibly dissociating the active tetramer into inactive monomers. This s...