Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico.

• Main Authors: Liliana E Villanueva-Lizama (Author), Julio V Cruz-Chan (Author), Amarú Del C Aguilar-Cetina (Author), Luis F Herrera-Sanchez (Author), Jose M Rodriguez-Perez (Author), Miguel E Rosado-Vallado (Author), Maria J Ramirez-Sierra (Author), Jaime Ortega-Lopez (Author), Kathryn Jones (Author), Peter Hotez (Author), Maria Elena Bottazzi (Author), Eric Dumonteil (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Trypanosoma cruzi antigens TSA-1 and Tc24 have shown promise as vaccine candidates in animal studies. We evaluated here the recall immune response these antigens induce in Chagasic patients, as a first step to test their immunogenicity in humans. We evaluated the in vitro cellular immune response af...