The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China

• Main Authors: Qingye Xu (Author), Xiaoting Hua (Author), Jintao He (Author), Di Zhang (Author), Qiong Chen (Author), Linghong Zhang (Author), Belinda Loh (Author), Sebastian Leptihn (Author), Yurong Wen (Author), Paul G. Higgins (Author), Yunsong Yu (Author), Zhihui Zhou (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Acinetobacter baumannii has emerged as a problematic hospital pathogen and tigecycline is among the few remaining antibiotics retaining activity against multidrug-resistant A. baumannii. This study was aimed to elucidate the tigecycline resistance mechanisms in 28 unique clinical A. bauma...