From Far West to East: Joining the Molecular Architecture of Imidazole-like Ligands in HO-1 Complexes

• Main Authors: Giuseppe Floresta (Author), Antonino Nicolò Fallica (Author), Vincenzo Patamia (Author), Valeria Sorrenti (Author), Khaled Greish (Author), Antonio Rescifina (Author), Valeria Pittalà (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

HO-1 overexpression has been reported in several cases/types of human malignancies. Unfortunately, poor clinical outcomes are reported in most of these cases, and the inhibition of HO-1 is considered a valuable and proven anticancer approach. To identify novel hit compounds suitable as HO-1 inhibito...