The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells

• Main Authors: Michela Asperti (Author), Luca Cantamessa (Author), Simone Ghidinelli (Author), Magdalena Gryzik (Author), Andrea Denardo (Author), Arianna Giacomini (Author), Giovanna Longhi (Author), Alessandro Fanzani (Author), Paolo Arosio (Author), Maura Poli (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ribonucleotide reductase (RR) is the rate-limiting enzyme that controls the deoxynucleotide triphosphate synthesis and it is an important target of cancer treatment, since it is expressed in tumor cells in proportion to their proliferation rate, their invasiveness and poor prognosis. Didox, a deriva...