Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations

• Главные авторы: Ajinkya Nitin Nikam (Автор), Angela Jacob (Автор), Ruchira Raychaudhuri (Автор), Gasper Fernandes (Автор), Abhijeet Pandey (Автор), Vinay Rao (Автор), Sheikh F. Ahmad (Автор), Ananth S. Pannala (Автор), Srinivas Mutalik (Автор)
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• Опубликовано: MDPI AG, 2023-08-01T00:00:00Z.
• Предметы: article
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5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe systemic side effects when administered through the intravenous route. Topical drug delivery could potentially mitigate the systemic side-effects. Microemulsions (MEs) would be an apt...