Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations

• Main Authors: Ajinkya Nitin Nikam (Author), Angela Jacob (Author), Ruchira Raychaudhuri (Author), Gasper Fernandes (Author), Abhijeet Pandey (Author), Vinay Rao (Author), Sheikh F. Ahmad (Author), Ananth S. Pannala (Author), Srinivas Mutalik (Author)
• Format: Bog
• Udgivet: MDPI AG, 2023-08-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe systemic side effects when administered through the intravenous route. Topical drug delivery could potentially mitigate the systemic side-effects. Microemulsions (MEs) would be an apt...